Psychosis Clinical &
Research Program

At PCRP, psychosis is treated like any other medical condition, with compassion, specialized expertise and multi-disciplinary care and innovation.

About Us

The Psychosis Clinical and Research Program (PCRP), co-led by Drs. Oliver Freudenreich and Daphne Holt, seeks to improve quality of life for people with psychosis or schizophrenia by reducing distressing symptoms, improving function in school, work and relationships, and promoting better physical health.

Our team of clinicians and researchers conducts state-of-the-art research focused on medication intervention trials, neuroscience and brain imaging, genetics and psychosocial interventions. We offer comprehensive diagnostic evaluations, second-opinion consultations, a clozapine clinic and ongoing treatment for adolescent and adult patients with psychosis, including schizophrenia and related disorders.

Clinical Services

Five specialized services support people across different stages and treatment needs. Select a service to learn more or begin a referral.

Resilience Evaluation-Social Emotional Training (RE-SET) Program

Evaluation and recommendations for young people experiencing changes that may indicate risk for psychosis or another neuropsychiatric condition.

  • Ages 12–30
  • Early changes or possible psychosis risk

First-Episode and Early Psychosis Program (FEPP)

Coordinated evaluation, treatment and recovery support for adolescents and adults experiencing psychosis for the first time.

  • Ages 14–35
  • First episode of psychosis

Recovery and Ongoing Care Clinic (ROCC)

Ongoing psychiatric medication care and group therapy for adults living with an established psychotic illness.

  • Ages 18 and older
  • Established psychotic illness

Psychosis Consultation Service

Patients and, when appropriate, family members meet with specialists for a one-time evaluation and recommendations. Recommendations are also communicated to the referring clinician.

  • Patients and families may ask their treating provider for a referral to the Psychosis Consultation Service
  • The treating psychiatric provider completes and submits the referral form

All referrals are screened for clinical appropriateness. Submitting a referral is not a guarantee of treatment. Patient and family consultation requests must be discussed with the current treating clinician.

Research at the PCRP

World-class researchers and caregivers work together to deepen our understanding of risk factors for psychosis, the full course of schizophrenia and related disorders, and to translate that understanding into compassionate, effective treatment. What makes our team unique is that many of our researchers are also clinicians who see patients.

Areas of Research

  • Emotion and Social Neuroscience Lab (ESNL) ↗, directed by Dr. Daphne Holt, studies emotion and social cognition in psychosis and related conditions using behavioral, physiological and neuroimaging methods.
  • Resilience and Prevention Program (RAPP) ↗, directed by Dr. Daphne Holt, studies mechanisms of risk and resilience and evaluates practical interventions designed to strengthen resilience and reduce risk for mental health challenges.
  • Intervention Clinical Trials Program seeks better medication options for schizophrenia symptoms and the medical problems associated with existing medications.
  • Early Brain Development Initiative ↗, directed by Dr. Joshua Roffman, aims to discover and implement prenatal and early-life interventions that may prevent neuropsychiatric illness.
  • Sleep, Cognition and Neuropsychiatry Lab (SCAN) ↗, directed by Dr. Dara Manoach, investigates how sleep and circadian physiology influence cognition and psychiatric symptoms, including cognitive difficulties in schizophrenia.
  • Center of Excellence for Psychosocial and Systemic Research ↗, directed by Dr. Cori Cather, develops and evaluates psychosocial interventions, quality-improvement initiatives and community-informed approaches to mental health care.

Meet Our Team

The Psychosis Clinical & Research Program includes expert clinicians who offer comprehensive diagnostic evaluations, second-opinion consultations and ongoing treatment for patients with schizophrenia and related disorders.

Portrait of Oliver Freudenreich, MD

Oliver Freudenreich, MD

Co-Director, Psychosis Clinical and Research Program

Director, TRS ACCESS Network

Professor of Clinical Psychiatry, Harvard Medical School

Portrait of Daphne Holt, MD, PhD

Daphne Holt, MD, PhD

Co-Director, Psychosis Clinical and Research Program

Professor of Psychiatry, Harvard Medical School

Portrait of Abigail Donovan, MD

Abigail Donovan, MD

Director, Acute Psychiatry Service

Director of Clinical Services, PCRP

Assistant Professor of Psychiatry, Harvard Medical School

Portrait of Cori Cather, PhD

Cori Cather, PhD

Director, Center of Excellence for Psychosocial and Systemic Research

Associate Professor of Psychology, Harvard Medical School

Portrait of Joshua Roffman, MD

Joshua Roffman, MD

Co-Director, Mass General Neuroscience

Director, Early Brain Development Initiative

Associate Professor of Psychiatry, Harvard Medical School

Meet the full team

Baktash Babadi, MD, PhD

Jacqueline Clauss, MD, PhD

Drew Coman, PhD

Nicole DeTore, PhD

Hamdi Eryilmaz, PhD

A. Eden Evins, MD, MPH

Cheryl Foo, PhD

Victoria Hasler, PhD

Marta Hernandez

Kelly Irwin, MD

Gina Kuperberg, MD, PhD

Carol Lim, MD, MPH

Thomas Damario

Dara Manoach, PhD

Sarah MacLaurin, PMHNP

Dimitrios Mylonas, PhD

Leah Namey

Elaine Shen, MD

Temitope Ogundare, MD

Shreedhar Paudel, MD, MPH

Katelyn Ragone

Faith Scanlon, PhD

John Tyson, MD

Lauren Utter, PsyD

Louis Vinke, PhD

Alexandra Volpacchio, PsyD

Patient & Family Resources

Schizophrenia and psychosis are serious, but also misunderstood, conditions. If you think a loved one is dealing with psychosis, it is vital to get help in the early stages of illness. Begin by learning more about schizophrenia and other forms of psychosis.

View our resources

Support Our Work

Families are our highest priority. We partner with patients to provide high-quality specialty care tailored to each family’s preferences and needs. Your support helps us expand care, education and research.

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